His most recent full-length album, Reunions (2020), is a critically-acclaimed collection of ten new songs that showcases an artist at the height of his powers and a band fully charged with creativity and confidence. In April of 2021, it was announced that Isbell would appear in the upcoming Martin Scorsese film, Killers of the Flower Moon.

In October 2021, Jason Isbell and the 400 Unit released a special new covers album, Georgia Blue. Created to celebrate Georgia’s role in the 2020 election, the record consists of new versions of thirteen songs with ties to the state, including tracks originally recorded by Georgia natives R.E.M., Drivn’ N’ Cryin’, James Brown, Cat Power, Precious Bryant, Otis Redding, The Black Crowes, Indigo Girls, Now It’s Overhead, Gladys Knight & The Pips, The Allman Brothers Band and Vic Chesnutt. All proceeds will benefit three non-profit organizations: Black Voters Matter, Fair Fight and Georgia STAND-UP.